This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access. (BOAI = Budapest Open Access Initiative)

Cautare in site:

Google:  Yahoo:  MSN:


   You are here: Home ›› Current edition ›› Vol. XXXII, No. 4 ›› 12KemerdereRahsan_Diagnostic
Diagnostic value of preoperative systemic inflammatory markers in patients with intracranial meningiomas
Rahsan Kemerdere1, Mehmet Yigit Akgun1, Sureyya Toklu1, Orkhan Alizada1, Oguz Baran2, Taner Tanriverdi1
1Department of Neurosurgery, Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, TURKEY
2Neurosurgery Clinic, Istanbul Research and Training Hospital, Istanbul, TURKEY
Introduction: The role of inflammation in cancer has been defined, and now, inflammation is accepted as one of the hallmarks of cancer development. The aim of this study was to evaluate the difference regarding preoperative neutrophil to lymphocyte (NLR) and platelet to lymphocyte ratios (PLR) in patients with meningioma between patients and healthy controls and between grade-I and grade-II meningiomas. Methods: Retrospective analysis of preoperative neutrophil, lymphocyte, monocyte, and platelet counts and NLR, and PLR were evaluated in 61 patients underwent meningioma surgery. Results: Neutrophil count was significantly increased while lymphocyte count significantly decreased patients compared to controls. Similar findings were obtained in grade-II meningiomas compared with grade-I meningiomas. NLR were significantly higher in both grade-I and grade-II meningiomas than controls. Conclusion: We for the first time provided that higher NLR may be associated with grading of meningioma and be a predictive factor for progression of meningiomas. The use of medication against neutrophil-related inflammation may be helpful for patients with higher grade of meningioma decreasing peritumoral edema before and after surgery.

Key words: Inflammation; Meningioma; Neutrophil-lymphocyte ratio; Platelet-lymphocyte ratio