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   You are here: Home ›› Current edition ›› Vol. XXXII, No. 4 ›› 11VukAleksic_Familial
Familial cerebral cavernous malformation syndrome in Serbian family
Aleksić Vuk1, Mandarić Aleksandar2, Mihajlović Miljan1, Aleksić Nemanja3, Rapaić Marko4, Jovančević Miroljub5, Stanić Milenko1, Samardžić Marko1, Popović Igor1, Miladinović Vladimir1, Spaić Milan1
1Department of Neurosurgery, Clinical Hospital Center Zemun, Belgrade, SERBIA
2Department of Radiology, Clinical Hospital Center Zemun, Belgrade, SERBIA
3Clinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade, SERBIA
4Faculty for Special Education and Rehabilitation, University of Belgrade, SERBIA
5Department of Radiology, “Euromedik” Hospital, Belgrade, SERBIA
Cavernomas are benign vascular malformations, and about 50% of all cases are multiple. The hereditary form of brain cavernomas is uncommon, and it is certainly under diagnosed. Another entity is familial cerebral cavernous malformation syndrome. It is defined as the occurrence of multiple cavernomas or the occurrence of cavernomas in at least two members of a family or the presence of a mutation in one of the three genes causing familial cerebral cavernous malformation syndrome. We present a Serbian family in which three consecutive members of family had brain cavernoma. According to our knowledge, this is second case of hereditary cavernoma described in Serbian population.

Key words: Cavernoma; Familial cerebral cavernous malformation syndrome; multiple cavernomas